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The National Centre for Airway Reconstruction comprises a multidisciplinary team of surgeons, physicians, anaesthetists, voice/swallowing therapists and researchers working across a group of hospitals in Central and West London. The lead for the unit is Mr Guri Sandhu, an ENT surgeon, based at Charing Cross Hospital (Imperial NHS Trust). Mr Sandhu has extensively researched the causes and treatment of adult laryngotracheal stenosis and has the greatest experience of this condition in the United Kingdom. The majority of stenosis can now be managed with minimally invasive endoscopic techniques. The more severely damaged airway may require open laryngotracheal reconstruction through resection or augmentation techniques.

Friday, 13 March 2009

Acquired Laryngotracheal Stenosis


Endotracheal intubation injury is the most common cause of acquired laryngotracheal stenosis in the developed world. The incidence is uncertain but estimated at 200 new cases per year in the United Kingdom.  Prospective studies have shown some sort of intubation injury in up to 40% of patients who have been ventilated on an Intensive Care Unit. Although the risk of significant airway injury correlates with duration of intubation, there does not appear to be a safe limit and significant injuries have been observed after only 8 hours of intubation in adults and 1 week in children. The incidence of airway stenosis following prolonged ventilation is estimated at 6-10%.

Symptoms related to airway stenosis can be subtle or cause severe shortness of breath. Subtle symptoms may be mistaken for asthma. Some patients may require surgery to insert a tracheostomy tube in the neck to allow them to breath.

 

 The majority of airway stenoses in the paediatric population are in the subglottis. Most are managed with augmentation using rib grafts. The most severe cases require tracheal or cricotracheal resection and anastamosis. Resection has in the past been the ‘Gold Standard’ in adults as rib grafts have poor survival rates. If this technique is applied to all cases of airway stenosis it has a variable success rate.

Airway injuries differ considerably in pathophysiology and degree and in our series more than 70% have been managed with endoscopic procedures alone. In adults having endoscopic airway surgery, in an appropriate centre, the complication rates and hospital stay are much reduced when compared with resection. Patients not suitable for an endoscopic approach are managed with augmentation techniques and resection is used as a last resort.

Thursday, 12 March 2009

Mr Sandhu

Mr Guri Sandhu  MBBS, FRCS (ORL-HNS)

Mr Sandhu has extensively researched the causes and treatment of adult laryngotracheal stenosis and has the greatest experience of this condition in the United Kingdom. The majority of stenosis can now be managed with minimally invasive endoscopic techniques. The more severely damaged airway may require open laryngotracheal reconstruction through resection or augmentation techniques.

The National Centre for Airway Reconstruction


The National Centre for Airway Reconstruction comprises a multidisciplinary team of surgeons, physicians, anaesthetists, voice/swallowing therapists and researchers working across a group of hospitals in Central and West London. The lead for the unit is Mr Guri Sandhu, an ENT surgeon, based at Charing Cross Hospital (Imperial NHS Trust). 

Mr Sandhu has extensively researched the causes and treatment of adult laryngotracheal stenosis and has the greatest experience of this condition in the United Kingdom. The majority of stenosis can now be managed with minimally invasive endoscopic techniques. The more severely damaged airway may require open laryngotracheal reconstruction through resection or augmentation techniques.

About Airway Stenosis


The human airway extends from the nose to the lungs. Narrowing (or stenosis) of the airway can occur anywhere along this path but more commonly involves the larynx (‘voicebox’) or trachea (‘windpipe’). Symptoms can be subtle but may include a degree of noisy breathing (stridor) and shortness of breath (dyspnoea). There is a variable impact on the voice and on the safety of swallowing. In severe cases a tracheotomy tube may be inserted in the neck to bypass the damaged airway.

Most commonly this condition is due to a period of ventilation on an Intensive Care Unit. However, inflammatory disorders such as Wegener’s granulomatosis, sarcoidosis and idiopathic subglottic stenosis are sometimes responsible.

Diagnosis is based on history and examination by a specialist. This may include the passing of a fibreoptic flexible endoscope (optical imaging device) into the airway. Special lung function tests (flow volume loops) and computer tomography (CT) scanning may help with the diagnosis. Definitive assessment requires examination of the airway under a short anaesthetic.